生物医学工程与诊断药学系

（1）Xingliang Liu, Shi Chen, Jing Huang, Yibo Du, Zhi Luo, Yue Zhang*, Lixin Liu*, Yongming Chen*. Synthetic polypeptides inhibit nucleic acid-induced inflammation in autoimmune diseases by disrupting multivalent TLR9 binding to LL37-DNA bundles. Nat. Nanotechnol. 2024. 19, 1745-1756. (IF = 38.1, Q1)

（2）Xingliang Liu#, Jing Huang#, Jiaqi Wang, Haonan Sheng, Zhen Yuan, Wanying Wang, Wenbin Li, Ziyuan Song*, Jianjun Cheng*. Accelerated and controlled polymerization of N-carboxyanhydrides assisted by acids. CCS Chem. 2024. https://doi.org/10.31635/ccschem.024.202403954 (IF = 9.4, Q1)

（3）Xingliang Liu, Shi Chen, Lixin Liu*, Yongming Chen*. Cationic brush hybrid nanoparticles scavenge cell-free DNA to enhance rheumatoid arthritis treatment. Acta Biomater., 2023, 170: 215-227. (IF = 9.4, Q1)

（4）Xingliang Liu, Shi Chen, Yanzi Yan, Lixin Liu*, Yongming Chen*, Nanoparticulate DNA scavenger loading methotrexate targets articular inflammation to enhance rheumatoid arthritis treatment, Biomaterials, 2022, 286: 121594. (IF = 12.8, Q1)

（5）Xingliang Liu, Huiyi Liang, Yanzi Yan, Jingjiao Wu, Massimo Bottini, Lixin Liu*, Yongming Chen*, The protein corona modulates the inflammation inhibition by cationic nanoparticles via cell-free DNA scavenging, Bioact. Mater., 2022, 13:249-259. (IF = 18, Q1)

（6）Chenxu Zhu, Chuang Li, Yibo Du, Shi Chen, Xingliang Liu, Lixin Liu*, Yongming Chen*. Precise Oligopeptides Block CCDC25 Interaction with DNA in Neutrophil Extracellular Traps Inhibiting Tumor Metastasis, ACS Appl. Mater. Interfaces, 2025, 17: 15208-15219. (IF = 8.5, Q2)

（7）Jing Huang, Xingliang Liu, Minzhao Lin, Zecong Xiao*, Xintao Shuai. Light-inducible nanodrug-mediated photodynamic and anti-apoptotic synergy for enhanced immunotherapy in triple-negative breast cancer. Biomater. Sci. 2024, 12: 2639-2647. (IF = 5.8, Q3)

（8）Yanzi Y, Huiyi Liang, Xingliang Liu, Lixin Liu, Yongming Chen*. Topical cationic hairy particles targeting cell free DNA in dermis enhance treatment of psoriasis, Biomaterials, 2021, 276: 121027. (IF = 12.8, Q1)

（9）YunKai Dai, Zhitao Hu, Xiaoying Wang, Xingliang Liu, Yuanchao Li, Yi Shi, Yongming Chen*, Synthesis of fully degradable cationic polymers with various topological structures via postpolymerization modification by using thio-bromo “click” reaction, Polym. Chem., 2021, 12(17): 2592-2597. (IF = 4.1, Q2)

（10）Zhicheng Le, Tong Xiao, Zhijia Liu, Xingliang Liu, Hong Liu, Lixin Liu, Yongming Chen*, Combinatorial synthesis of redox-responsive cationic polypeptoids for intracellular protein delivery application, Sci. China Chem., 2020, 63(11): 1619-1625. (IF = 10.4, Q1)

（11）Xiaojie Li*, Xingliang Liu, Dongjian Shi, Wei Wei, Mingqing Chen, Xiaoya Liu, Facile synthesis of hyperbranched polymers by sequential polycondensation, ACS Macro Lett., 2018, 7, 778-782. (IF = 5.1, Q1)

刘兴亮
特聘研究员
院系：生物医学工程与诊断药学系
招生方向：仿生聚氨基酸材料的制备；聚氨基酸的合成方
实验室：
电子邮箱：liuxingliang@cpu.edu.cn
办公室：
个人简介

   刘兴亮博士，中国药科大学工学院特聘研究员、兴药青创学者、博士生导师。2022年于中山大学材料科学与工程学院获得博士学位（导师：陈永明教授），2022年-2024年于西湖大学工学院从事博士后研究（合作导师：程建军教授）。2025年-至今在中国药科大学，工学院，生物医学工程与诊断药学系开展独立研究工作，主要从事高分子聚合物材料的化学合成和结构设计，在聚氨基酸的合成方法学、阳离子聚合物设计和生物医学应用等方向有深入研究。迄今为止在Nature nanotechnology、CCS Chemistry、Bioactive materials等国际知名学术期刊发表多篇论文，获中国授权专利3项，美国授权专利1项。

研究方向

1. 仿生聚氨基酸材料的制备。

2. 聚氨基酸的合成方法学、聚合机理研究。

3. 游离核酸在自身免疫性疾病中的作用及聚合物材料的干预治疗。

承担项目情况

   主持中国博士后科学基金面上资助、江苏省研究生培养创新项目。

代表性科研成果

（1）Xingliang Liu, Shi Chen, Jing Huang, Yibo Du, Zhi Luo, Yue Zhang*, Lixin Liu*, Yongming Chen*. Synthetic polypeptides inhibit nucleic acid-induced inflammation in autoimmune diseases by disrupting multivalent TLR9 binding to LL37-DNA bundles. Nat. Nanotechnol. 2024. 19, 1745-1756. (IF = 38.1, Q1)

（2）Xingliang Liu#, Jing Huang#, Jiaqi Wang, Haonan Sheng, Zhen Yuan, Wanying Wang, Wenbin Li, Ziyuan Song*, Jianjun Cheng*. Accelerated and controlled polymerization of N-carboxyanhydrides assisted by acids. CCS Chem. 2024. https://doi.org/10.31635/ccschem.024.202403954 (IF = 9.4, Q1)

（3）Xingliang Liu, Shi Chen, Lixin Liu*, Yongming Chen*. Cationic brush hybrid nanoparticles scavenge cell-free DNA to enhance rheumatoid arthritis treatment. Acta Biomater., 2023, 170: 215-227. (IF = 9.4, Q1)

（4）Xingliang Liu, Shi Chen, Yanzi Yan, Lixin Liu*, Yongming Chen*, Nanoparticulate DNA scavenger loading methotrexate targets articular inflammation to enhance rheumatoid arthritis treatment, Biomaterials, 2022, 286: 121594. (IF = 12.8, Q1)

（5）Xingliang Liu, Huiyi Liang, Yanzi Yan, Jingjiao Wu, Massimo Bottini, Lixin Liu*, Yongming Chen*, The protein corona modulates the inflammation inhibition by cationic nanoparticles via cell-free DNA scavenging, Bioact. Mater., 2022, 13:249-259. (IF = 18, Q1)

（6）Chenxu Zhu, Chuang Li, Yibo Du, Shi Chen, Xingliang Liu, Lixin Liu*, Yongming Chen*. Precise Oligopeptides Block CCDC25 Interaction with DNA in Neutrophil Extracellular Traps Inhibiting Tumor Metastasis, ACS Appl. Mater. Interfaces, 2025, 17: 15208-15219. (IF = 8.5, Q2)

（7）Jing Huang, Xingliang Liu, Minzhao Lin, Zecong Xiao*, Xintao Shuai. Light-inducible nanodrug-mediated photodynamic and anti-apoptotic synergy for enhanced immunotherapy in triple-negative breast cancer. Biomater. Sci. 2024, 12: 2639-2647. (IF = 5.8, Q3)

（8）Yanzi Y, Huiyi Liang, Xingliang Liu, Lixin Liu, Yongming Chen*. Topical cationic hairy particles targeting cell free DNA in dermis enhance treatment of psoriasis, Biomaterials, 2021, 276: 121027. (IF = 12.8, Q1)

（9）YunKai Dai, Zhitao Hu, Xiaoying Wang, Xingliang Liu, Yuanchao Li, Yi Shi, Yongming Chen*, Synthesis of fully degradable cationic polymers with various topological structures via postpolymerization modification by using thio-bromo “click” reaction, Polym. Chem., 2021, 12(17): 2592-2597. (IF = 4.1, Q2)

（10）Zhicheng Le, Tong Xiao, Zhijia Liu, Xingliang Liu, Hong Liu, Lixin Liu, Yongming Chen*, Combinatorial synthesis of redox-responsive cationic polypeptoids for intracellular protein delivery application, Sci. China Chem., 2020, 63(11): 1619-1625. (IF = 10.4, Q1)

（11）Xiaojie Li*, Xingliang Liu, Dongjian Shi, Wei Wei, Mingqing Chen, Xiaoya Liu, Facile synthesis of hyperbranched polymers by sequential polycondensation, ACS Macro Lett., 2018, 7, 778-782. (IF = 5.1, Q1)