教授/研究员

1. Yu, H.; Tiemuer, A.; Yao, X. F.; Zuo, M. Y.; Wang, H. Y.; Liu, Y.; Chen, X. Y. Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy. Acta Pharm. Sin. B, 2024,14(1): 378-391. (IF=14.50)

2. Chai, Y.; Shangguan. L. N.; Yu, H.; Sun, Y.; Huang, X. Y.; Zhu, Y. Y.; Wang, H. Y.; Liu, Y. Near Infrared Light-Activatable Platelet-Mimicking NIR-II NO Nano-Prodrug for Precise Atherosclerosis Theranostics. Adv. Sci., 2024, 11: 2304994. (IF=15.10)

3. Wang, J.; Sheng, Z.; Guo, J.; Wang, H. Y.; Sun, X. L.; Liu, Y. Near-infrared fluorescence probes for monitoring and diagnosing nephron-urological diseases. Coord. Chem. Rev., 2023, 486, 215137. (IF=20.60)

4. Yu, H.; Chai, Y.; Tiemuer, A.; Han, Y.; Wang, H. Y.; Liu, Y. Frequency upconversion luminescence: New frontiers in bioapplications. Coord. Chem. Rev., 2023, 496, 215379 . (IF=20.60)

5. Tan, B. J; Zhao, C.; Wang, J.; Aliya, T.; Zhang, Y. Y.; Yu, H.; Liu, Y. Rational Design of pH-Activated Upconversion Luminescent Nanoprobes for Bioimaging of Tumor Acidic Microenvironment and the Enhancement of Photothermal Therapy. Acta Biomater., 2023, 155, 554-563. (IF=10.63)

6. Ma, Y.; Ma, Y. X.; Gao, M. Q.; Han, Z. H.; Jiang, W.; Gu, Y. Q.; Liu, Y. Platelet-Mimicking Therapeutic System for Noninvasive Mitigation of the Progression of Atherosclerotic Plaques. Adv. Sci. 2021, 8(8): 2004128. (IF=16.81)

7. Tiemuer A.; Yu, H.; Zhao, C.; Sun, W. L.; Zhang, Y. Y.; Jiang, Y. M.; Gu, Y. Q.; Liu, Y. Nitroso-Caged Upconversion Luminescent Prodrug: Near Infrared Light-Activatable NO Nano-Donor for Gas Therapy. Chem. Eng. J., 2021, 132858. (IF=13.27)

8. Zhou, F. Y.; Yang, S. K.; Zhao, C.; Liu, W. W.; Yao, X. F.; Yu, H.; Sun, X. L.; Liu, Y. γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy. Theranostics, 2021, 11(14): 7045-7056. (IF=11.56)

9. Liu, Y.; Wang, S.; Ma, Y.; Lin, J.; Wang, H. Y.; Gu, Y. Q.; Chen, X. Y.; Huang, P. Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Zebrafish. Adv. Mater., 2017, 29(17): 1606129. (IF=30.85)

10. Liu, Y.; Su, Q. Q.; Chen, M.; Dong, Y.; Shi, Y. B.; Feng, W.; Wu, Z-Y.; Li, F. Y. Near-Infrared Upconversion Chemodosimeter for in vivo Detection of Cu2+ in Wilson Disease. Adv. Mater., 2016, 28, 6625. (IF=30.85)

11. Liu, Y.; Chen, M.; Cao, T. Y.; Sun. Y.; Li, C. Y.; Liu, Q.; Yang, T. S.; Yao, L. M.; Feng, W.; Li, F. Y.*, A Cyanine-Modified Nnaosystem for in vivo Upconversion Luminescence Bioimaging of Methylmercury, J. Am. Chem. Soc., 2013, 135, 9869. (IF=15.42)


刘熠
教授
院系：工学院
招生方向：制药工程学
实验室：实训楼507
电子邮箱：yiliu@cpu.edu.cn
办公室：实训楼404
个人简介

刘熠，男，博士，教授，博士生导师，现工作于工学院生物医学工程与诊断药学系。2014年毕业于复旦大学化学系，导师是黄春辉院士和李富友教授。同年进入美国国立卫生研究院（NIH）陈小元课题组从事博士后工作。主持国家自然科学基金、江苏省自然科学基金等多项基金，入选江苏省“六大人才高峰”和“333高层次”人才项目。以第一作者或通讯作者身份在JACS, Adv. Mater., Adv. Sci., Chem. Eng. J.和Theranostics等国际权威期刊发表高水平SCI论文30余篇，论文被引用近4000余次。应邀成为ACS Nano，Chem. Sci.，Adv. Sci.，Biomaterials等专业杂志的审稿人；被聘为中国生物医学工程生物光子分会青年委员和中国医药生物技术协会纳米生物技术分会委员。


研究方向

1.小分子探针用于病理靶标分子的体外诊断和活体监测。

2.响应型有机功能材料用于疾病的早期诊断和精准治疗。



承担项目情况

1. 国家科学基金面上项目（81771900, 82272148 ）；

2. 国家科学基金青年项目（81601531）；

3. 江苏省青年科学基金项目（BK20160755）；

4. 江苏省“六大人才高峰”项目（SWYY-063）；

5. 中国药科大学人才引进启动经费；



代表性科研成果

1. Yu, H.; Tiemuer, A.; Yao, X. F.; Zuo, M. Y.; Wang, H. Y.; Liu, Y.; Chen, X. Y. Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy. Acta Pharm. Sin. B, 2024,14(1): 378-391. (IF=14.50)

2. Chai, Y.; Shangguan. L. N.; Yu, H.; Sun, Y.; Huang, X. Y.; Zhu, Y. Y.; Wang, H. Y.; Liu, Y. Near Infrared Light-Activatable Platelet-Mimicking NIR-II NO Nano-Prodrug for Precise Atherosclerosis Theranostics. Adv. Sci., 2024, 11: 2304994. (IF=15.10)

3. Wang, J.; Sheng, Z.; Guo, J.; Wang, H. Y.; Sun, X. L.; Liu, Y. Near-infrared fluorescence probes for monitoring and diagnosing nephron-urological diseases. Coord. Chem. Rev., 2023, 486, 215137. (IF=20.60)

4. Yu, H.; Chai, Y.; Tiemuer, A.; Han, Y.; Wang, H. Y.; Liu, Y. Frequency upconversion luminescence: New frontiers in bioapplications. Coord. Chem. Rev., 2023, 496, 215379 . (IF=20.60)

5. Tan, B. J; Zhao, C.; Wang, J.; Aliya, T.; Zhang, Y. Y.; Yu, H.; Liu, Y. Rational Design of pH-Activated Upconversion Luminescent Nanoprobes for Bioimaging of Tumor Acidic Microenvironment and the Enhancement of Photothermal Therapy. Acta Biomater., 2023, 155, 554-563. (IF=10.63)

6. Ma, Y.; Ma, Y. X.; Gao, M. Q.; Han, Z. H.; Jiang, W.; Gu, Y. Q.; Liu, Y. Platelet-Mimicking Therapeutic System for Noninvasive Mitigation of the Progression of Atherosclerotic Plaques. Adv. Sci. 2021, 8(8): 2004128. (IF=16.81)

7. Tiemuer A.; Yu, H.; Zhao, C.; Sun, W. L.; Zhang, Y. Y.; Jiang, Y. M.; Gu, Y. Q.; Liu, Y. Nitroso-Caged Upconversion Luminescent Prodrug: Near Infrared Light-Activatable NO Nano-Donor for Gas Therapy. Chem. Eng. J., 2021, 132858. (IF=13.27)

8. Zhou, F. Y.; Yang, S. K.; Zhao, C.; Liu, W. W.; Yao, X. F.; Yu, H.; Sun, X. L.; Liu, Y. γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy. Theranostics, 2021, 11(14): 7045-7056. (IF=11.56)

9. Liu, Y.; Wang, S.; Ma, Y.; Lin, J.; Wang, H. Y.; Gu, Y. Q.; Chen, X. Y.; Huang, P. Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Zebrafish. Adv. Mater., 2017, 29(17): 1606129. (IF=30.85)

10. Liu, Y.; Su, Q. Q.; Chen, M.; Dong, Y.; Shi, Y. B.; Feng, W.; Wu, Z-Y.; Li, F. Y. Near-Infrared Upconversion Chemodosimeter for in vivo Detection of Cu2+ in Wilson Disease. Adv. Mater., 2016, 28, 6625. (IF=30.85)

11. Liu, Y.; Chen, M.; Cao, T. Y.; Sun. Y.; Li, C. Y.; Liu, Q.; Yang, T. S.; Yao, L. M.; Feng, W.; Li, F. Y.*, A Cyanine-Modified Nnaosystem for in vivo Upconversion Luminescence Bioimaging of Methylmercury, J. Am. Chem. Soc., 2013, 135, 9869. (IF=15.42)