顾月清教授,中国药科大学工学院院长，二级教授，江苏省“333”第一层次培养对象，江苏省“青蓝工程”学科带头人。多个国家级学术团体的常务理事、理事。《激光生物学报》、《生物技术通讯》、国际影像学杂志AJNMMI、《中国药科大学学报》等编委。先后获江苏省科技进步奖、教育部自然科学奖、中国产学研创新奖等。近年来一直致力于肿瘤早期诊断探针及靶向前药的研究，将分子影像技术、生物信息学等融合到药物研究各领域，开发了多种活细胞、活体检测分子探针，并自行研制相关仪器，结合各种抗癌药物及纳米载体研究靶向抗肿瘤前药。近几年，主持多项国家级重点项目，包括973 课题、国家重大科研仪器研制项目、国家自然科学基金重大研发计划、国自然重点项目、重大国际合作基金、重大研究计划、海外及港澳

合作研究项目等。已申请多项国家发明专利、国际专利（ PCT ）等，体外HPV宫颈癌筛查诊断试剂盒、手术导航荧光探针等正进行临床转化。近5年在国际权威杂志发表了SCI收录论文100多篇，包括Angew. Chem. Int. Ed , ACS Nano，Cancer Research，Advanced Material, Biomaterials，Theranotics，J. Controlled Release, Advanced Science等高水平论文。

正在承担或完成的主要研究项目：

2013-2017年，国自然国际（地区）重大合作与交流项目(NSFC 81220108012)：面向乳腺癌高转移机制的量子点活体标记新方法的基础研究； 主持，280万；

2014-2018年，国自然重点项目（NSFC61335007）：基于上转换纳米粒的深层肿瘤光动力学治疗量效关系的基础研究；主持，260万；

2015-2019年，科技部国家重点基础研究计划（973计划）（2015CB755504）：脑胶质瘤精准诊疗技术的关键科学问题研究/课题四--颅内精准给药治疗技术;

课题负责人，600万；

2018-2022年，国家重大科研仪器研制项目(NSFC81727804): 纳米药物活体小动物动力学转运特性多尺度成像系统的研制；主持，804万

2018-2021年，国自然海外及港澳学者合作研究基金（延续资助NSFC81729002）：结肠炎癌转化相关炎症因子的筛选、监测及早期干预逆转策略的研究；中方负责人，180万；

2019-2022年，国家自然科学基金重大研究计划（NSFC）: 结直肠炎癌转化关键因子的可视化及病理诊断；主持，300万；

近几年发表的文章（Peer reviewed Publication）

2020

[1] Hu F., Zhang W., Meng W.,Gu Y.*,et al. Ferrocene-labeled and purification-free electrochemical biosensor based on ligase chain reaction for ultrasensitive single nucleotide polymorphism detection[J]. Analytica Chimica Acta, 2020, 1109: 9-18.IF=5.26

[2] Wang H., Wang Z., Tu Y.,Gu Y.*, et al. Homotypic targeting upconversion nano-reactor for cascade cancer starvation and deep-tissue phototherapy[J]. Biomaterials, 2020, 235: 119765.IF=10.273

[3] Liu Y., Wu H., Zhang W.,Gu Y.*, et al. Endonuclease-assisted hydrogel bead array for digital analysis of circulating tumor DNA methylation[J]. Sensors And Actuators B-Chemical, 2020, 304.IF=6.393

[4] Tu Y., Tao J., Wang F.,Gu Y.*, et al. A novel peptide targeting gastrin releasing peptide receptor for pancreatic neoplasm detection[J]. Biomater Sci, 2020.IF=5.251

[5] Xu T., Ma Y., Yuan Q.,Gu Y.*, Li S.*, et al. Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy[J]. ACS Nano, 2020, 14(3): 3414-3425IF=13.903

2019

[1] Zhang M., Ma Y., Wang Z.,Gu Y.*, et al. A CD44-Targeting Programmable Drug Delivery System for Enhancing and Sensitizing Chemotherapy to Drug-Resistant Cancer[J]. Acs Applied Materials & Interfaces, 2019, 11(6): 5851-5861. IF=8.456

[2] Wang H., Li Y., Yang M.,Gu Y.*, et al. FRET-Based Upconversion Nanoprobe Sensitized by Nd3+ for the Ratiometric Detection of Hydrogen Peroxide in Vivo[J]. Acs Applied Materials & Interfaces, 2019, 11(7): 7441-7449. IF=8.456

[3] Li P., Yu X., Han W.,Gu Y.*, et al. Ultrasensitive and Reversible Nanoplatform of Urinary Exosomes for Prostate Cancer Diagnosis[J]. Acs Sensors, 2019, 4(5): 1433-1441.IF=6.944

[4] Yang M., Wang H., Wang Z.,Gu Y.*, et al. A Nd3+ sensitized upconversionnanosystem with dual photosensitizers for improving photodynamic therapy efficacy[J]. Biomaterials Science, 2019, 7(4): 1686-1695. IF=5.251

[5] Zhang Q., Han Z., Tao J.,Gu Y.*, et al. An innovative peptide with high affinity to GPC3 for hepatocellular carcinoma diagnosis[J]. Biomaterials Science, 2019, 7(1): 159-167.IF=5.251

[6] Wang H., Wang Z., Li Y.,Gu Y.*, et al. A Novel Theranostic Nanoprobe for In Vivo Singlet Oxygen Detection and Real-Time Dose-Effect Relationship Monitoring in Photodynamic Therapy[J]. Small, 2019, 15(39). IF=10.856

[7] Wang Z., Ma Y., Wang H.,Gu Y.*, et al. CXCR4-Enriched Nano-Trap Targeting CXCL12 in Lung for Early Prevention and Enhanced Photodynamic Therapy of Breast Cancer Metastasis[J]. Advanced Functional Materials, 2019, 29(45). IF=15.621

2018

[1] Ma Y., Wang Z., Ma Y., Gu Y.*, et al. A Telomerase-Responsive DNA Icosahedron for Precise Delivery of Platinum Nanodrugs to Cisplatin-Resistant Cancer[J]. Angew Chem Int Ed Engl, 2018, 57(19): 5389-5393.IF=12.257

[2] Wang Z., Ma Y., Yu X.,Gu Y.*, et al. Targeting CXCR4-CXCL12 Axis for Visualizing, Predicting, and Inhibiting Breast Cancer Metastasis with Theranostic AMD3100-Ag2S Quantum Dot Probe[J]. Advanced Functional Materials, 2018, 28(23).IF=15.621

[3] Wang H., Liu Y., Wang Z., Gu Y.*,et al. 808 nm-light-excited upconversion nanoprobe based on LRET for the ratiometric detection of nitric oxide in living cancer cells[J]. Nanoscale, 2018, 10(22): 10641-10649. IF=6.97

[4] Li S., Liu Y., Rui Y.,Gu Y.*,et al. Dual target gene therapy to EML4-ALK NSCLC by a gold nanoshell-based system[J]. Theranostics, 2018, 8(10): 2621-2633.IF=8.063

[5] Hu F., Zhang W., Zhang J.,Gu Y.*, et al. An electrochemical biosensor for sensitive detection of microRNAs based on target-recycled non-enzymatic amplification[J]. Sensors And Actuators B-Chemical, 2018, 271: 15-23.IF=6.393

[6] Ma Y., Zhao Y., Xia L.,Gu Y.*, et al. A novel one- and two-photon fluorescent probe induced by light for selective imaging of Cys in living cells and tissues[J]. Analytica Chimica Acta, 2018, 1035: 161-167.IF=5.256

[7] Zhang W., Zhang J., Zhang Q.,Gu Y.*, et al. Highly specific real-time qualification of diverse microRNAs in tissue and serum using universal molecular beacon[J]. Sensors And Actuators B-Chemical, 2018, 262: 153-161.IF=6.393

[8] Zhang W., Hu F., Zhang Q.,Gu Y.*, et al. Sensitive and specific detection of microRNAs based on two-stage amplification reaction using molecular beacons as turn-on probes[J]. Talanta, 2018, 179: 685-692.IF=4.912

2017

[1] Y. Liu, S. Wang, Y. Ma, J. Lin, H.-Y. Wang, Y. Gu, X. Chen, P. Huang, Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Living Subjects, Advanced materials, (2017) 1606129.IF=25.809

[2] S. Li, S. Cui, d. yin, Q. Zhu, Y. Ma, Z. Qian, Y. Gu, Dual Antibacterial Activities of Chitosan-Modified Upconversion Photodynamic Therapy System against Drug-resistant Bacteria in Deep Tissue, Nanoscale, 2017.IF=6.97

[3] Yi Ma, Guanhua Ai, Congying Zhang, Menglu Zhao, Xue Dong, Zhihao Han, Zhaohui Wang, Min Zhang, Yuxi Liu, Weidong Gao, Siwen Li, Yueqing Gu* Novel Linear Peptides with High Affinity to αvβ3 Integrin for Precise Tumor Identification. Theranostics, Accepted manuscript, doi:10.7150/thno.18401. IF=8.063

2016

[1] D. Chen, B. Li, S. Cai, P. Wang, S. Peng, Y. Sheng, Y. He, Y. Gu, H. Chen, Dual targeting luminescent gold nanoclusters for tumor imaging and deep tissue therapy, Biomaterials, 100 (2016) 1-16.IF=10.273

[2] W. Gao, Z. Wang, L. Lv, D. Yin, D. Chen, Z. Han, Y. Ma, M. Zhang, M. Yang, Y. Gu, Photodynamic Therapy Induced Enhancement of Tumor Vasculature Permeability Using an Upconversion Nanoconstruct for Improved Intratumoral Nanoparticle Delivery in Deep Tissues, Theranostics, 6 (2016) 1131-1144.IF=8.063

[3] S. Li, S. Feng, L. Ding, Y. Liu, Q. Zhu, Z. Qian, Y. Gu, Nanomedicine engulfed by macrophages for targeted tumor therapy, International journal of nanomedicine, 11 (2016) 4107-4124.IF=4.471

[4] Y. Liu, S. Li, D. Chen, Z. Wang, J. Zhang, C. Tian, L. Ding, Y. Chen, Z. Qian, Y. Gu, Clinical diagnosis of EML4–ALK mutation in NSCLC by a gold nanoparticle beacon, RSC Adv., 6 (2016) 102398-102405.IF=3.049

[5] Y. Ma, Z. Wang, M. Zhang, Z. Han, D. Chen, Q. Zhu, W. Gao, Z. Qian, Y. Gu, A Telomerase-Specific Doxorubicin-Releasing Molecular Beacon for Cancer Theranostics, Angewandte Chemie, 55 (2016) 3304-3308.IF=12.257

[6] P. Wang, J. Huang, K. Wang, Y. Gu, New palbociclib analogues modified at the terminal piperazine ring and their anticancer activities, European journal of medicinal chemistry, 122 (2016) 546-556.IF=4.833

[7] Z. Wang, S. Li, M. Zhang, Y. Ma, Y. Liu, W. Gao, J. Zhang, Y. Gu, Laser-Triggered Small Interfering RNA Releasing Gold Nanoshells against Heat Shock Protein for Sensitized Photothermal Therapy, Advanced Science, (2016) 1600327.IF=15.804

[8] Q. Zhou, Y. Ma, Z. Wang, K. Wang, R. Liu, Z. Han, M. Zhang, S. Li, Y. Gu, Optimized Ultrasound Conditions for Enhanced Sensitivity of Molecular Beacons in the Detection of MDR1 mRNA in Living Cells, Analytical chemistry, 88 (2016) 2808-2816.IF=6.35