(1) Qing Li, Yuting Zhao, Xinyu Zhu, Sheng Jiang, Tianyu Wang, Dawei Deng*, Xiangyu Zhang*, Traceless Nitro Group Directing Strategy: Modular Syntheses of the Scaffolds of Polycyclic Alkaloids Org. Lett. 2025, doi: 10.1021/acs.orglett.5c02174 (封面文章)
(2) Zhihao Qi, Yao Cheng, Kaizhen Wang, Shi Cai, Xiang Ni, Tianyu Wang, Kuojun Zhang, Sheng Jiang*, Yibei Xiao*, and Xiangyu Zhang*, Discovery, Synthesis, and Activity Evaluation of Novel Small-Molecule Inhibitors Targeting VISTA for Cancer Immunotherapy J. Med. Chem. 2025, 68, 5222-5237.
(3) Xiangyu Zhang; Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours, Nat. Prod. Rep. 2024, 41, 784.
(4) Kaizhen Wang, Shi Cai, Yao Cheng, Zhihao Qi, Xiang Ni, Kuojun Zhang, Yibei Xiao,* Xiangyu Zhang,* Tianyu Wang* Discovery of Benzo[d]oxazoles as Novel Dual Small-Molecule Inhibitors Targeting PD-1/PD-L1 and VISTA Pathway J. Med. Chem. 2024, 67, 18526–18548.
(5) Tianyu Wang; Kaizhen Wang; Yu Zhang; Kuojun Zhang; Shi Cai; Sheng Jiang*; Yibei Xiao*; Xiangyu Zhang*; Novel Benzimidazoles as Potent Small-Molecule Inhibitors and Degraders of V-Domain Ig Suppressor of T-Cell Activation (VISTA). J. Med. Chem. 2023, 66, 11881-11892.
(6) Kaizhen Wang1; Xiangyu Zhang1; Yao Cheng1; Zhihao Qi1; Ke Ye; Kuojun Zhang; Sheng Jiang; Yi Liu; Yibei Xiao; Tianyu Wang; Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy. J. Med. Chem. 2023, 66, 16807-16827.
(7) Kaizhen Wang1; Ke Ye1; Xiangyu Zhang1; Tianyu Wang; Zhihao Qi; Youjun Wang; Sheng Jiang*and Kuojun Zhang*; Dual Nicotinamide Phosphoribosyltransferase (NAMPT) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors for the Treatment of Drug-Resistant Nonsmall-Cell Lung Cancer. J. Med. Chem. 2023, 66, 1027.
(8) Kuojun Zhang; Tianyu Wang; Maotian Li; Mu Liu; He Tang; Lin Wang; Ke Ye; Jiamei Yang; Sheng Jiang; Yibei Xiao; Youhua Xie; Meiling Lu; Xiangyu Zhang; Discovery of quinazolin-4-onebased non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro). Eur. J. Med. Chem. 2023, 257: 115487.
(9) Shi Cai; Kaizhen Wang; Zhihao Qi; Ke Ye; Xinyuan Zhou; Sheng Jiang; Kuojun Zhang*; Xiangyu Zhang*; Tianyu Wang*, Design, synthesis, and evaluation of PD-1/PD-L1 small-molecule inhibitors bearing a rigid indane scaffold. Eur. J. Med. Chem. 2023, 256, 115468.
(10) Xiangyu Zhang; James C. Anderson, A Divergent Synthetic Route to the Vallesamidine and Schizozygine Alkaloids: Total Synthesis of (+)-Vallesamidine and (+)-14,15-Dehydrostrempeliopine., Angew. Chem. Int. Ed. 2019, 58, 18040-18045 [Synfact 2025, 21, 763亮点文章收录]