
蔡挺, 中国药科大学教授,工学院院长,博士生导师,教育部青年长江学者,江苏省特聘教授,江苏省杰出青年基金获得者,江苏省双创团队领军人才, 江苏省333工程第二层次人才,南京市有突出贡献中青年专家。现任中国药科大学教育部智能制药工程研究中心副主任。专业研究领域为物理药剂学、工业药剂学、制剂工程学,围绕药物新型剂型设计、稳定性和释放等关键科学问题,开展理论及应用研究。本科毕业于复旦大学, 博士毕业于美国弗吉尼亚理工大学化学系,后在美国威斯康辛大学麦迪逊分校药学院从事药剂博士后研究工作。回国工作前就职于美国制药公司, 工作期间主导多项复杂制剂研发工作。已在JACS、Angew、Adv Mater等国际知名药学及相关领域期刊发表SCI论文90多篇,引用3000多次。作为项目负责人主持国家新药创制重大专项、国家自然科学基金面上项目、江苏省前沿技术重大专项等项目等多项国家和10多企业合作课题;获得中国药物制剂大会“青年药剂学奖”,江苏省生物技术协会科技创新奖一等奖和“江苏省归侨侨眷先进个人”等荣誉;目前担任药剂学杂志Molecular Pharmaceutics,Pharmaceutical Research, Journal of Pharmaceutical Sciences,Asian Journal of Pharmaceutical Sciences,Chinese Chemical Letters,《中国药科大学学报》、《药学进展》、《药学学报中英文版》、《中国现代应用药学》编委。目前担任江苏省生物技术协会青年专委会主任委员,中国药学会制药工程专委会委员,中国晶体协会药物晶体学专业委员会常务委员,中国药学会药剂专委会青年委员。
招生方向:
学硕:100702药剂学、1007Z1制药工程学
专硕:105500-02工业药剂学、086000-002生物与医药-制药工程和工艺
课题组围绕药剂学和制剂工程学领域的前沿科学问题,利用先进的理化技术手段,开展理论和应用研究工作。主要研究内容包括:
(1)药物晶型及固态化学研究
(2)难溶性药物制剂研究
(3)缓控释及长效制剂研究
(4)药品质量控制与先进制造
(5)药物新制剂与新技术
(1)江苏省前沿技术研发计划,项目编号:BF2024075,500万,主持
(2)国家自然科学基金面上项目,项目编号:22478439,50万,主持
(3)国家自然科学基金面上项目,项目编号:82273880 52万,主持
(4)高端外国专家引进计划, 项目编号:G2021146003L,40 万,主持,
(5)江苏省杰出青年基金项目,项目编号:BK20190029, 100万,主持,
(6)国家自然科学基金面上项目,项目编号:81872813,57万,主持,
(7)科技部十三五“重大新药创制”科技重大专项,项目编号:2017ZX09301075,294.78万
1. Yang, Y.; Long, W.; Pei, X.; Li, S.; Fu, B.; Zhai, H.; Zhang, X.; Wan, Y.; Peng, Y.;* Cai, T.* Atorvastatin-Loaded Mineralized Vaccine Reprograms Endosomal Trafficking to Amplify STING-Driven Cancer Immunotherapy, Angew. Chem. Int. Ed. 2025, e202503749
2. Meng, J.; Su, Y.; Zhu, H.; Zhang, J.; Cai, T.* Dynamic Molecular Cocrystals with Alkyl Chain Dependent Thermosalient Phase Transitions Advanced Science, 2025, 02502692
3. Fan, F.; Lu, Y.; Xu, S.; Guo, M.; Cai, T.* Impact of Polymers on the Kinetics of the Solid-State Phase Transition of Piracetam Polymorphs, Molecular Pharmaceutics, 2025, 22, 509
4. Peng, Y.; Yao, X.; Hu, X.; Wu, B.; Pei, X.; Yang, Y.; Dong, Z.; An, Z.;* Huang, W.;* Cai, T.* Edible Ultralong Organic Phosphorescent Excipient for Afterglow Visualizing the Quality of Tablets Advanced Materials, 2024, 36, 40, 202406618
5. Su,Y.; Li, S.; Li, X.; Zhou, J.; Chauhan, V.P.; Li, M.; Su, Y.H.; Liu, C.M.; Ren, Y.F.; Yin, W.;* Rimer, J.D.;* Cai, T.* Tartronic acid as a Potential Inhibitor of Pathological Calcium Oxalate Crystallization Advanced Science, 2024, 2400642
6. Meng, J.; Su, Y.; Zhu, H.; Cai, T.* Shape Memory and Self-Healing in a Molecular Crystal with Inverse Temperature Symmetry Breaking Chemical Science, 2024 15, 5738
7. Chen, A.; Cai, P.; Peng, Y.; Guo, M.; Su, Y.;* Cai, T.* The role of alkyl chain length in the melt and solution crystallization of paliperidone aliphatic Prodrugs, IUCrJ, 2024, 11, 23
8. Luo, M.; Chen, A.; Huang, C.; Guo, M.; Cai, T.* Effects of Polymers on Cocrystal Growth in a Drug−Drug Coamorphous System: Relations between Glass-to-Crystal Growth and Surface-Enhanced Crystal Growth, Molecular Pharmaceutics, 2024, 21, 3591
9. Peng, Y.; Lei, Y.; Luo, J.; Hu, X.; Sun, F.; Yang, Y.; Guo, M.; Cai, T.* The inherent AIE feature revealed the drug molecular state in cyclodextrin metal–organic framework for enhanced stability and absorption, Chemical Engineering Journal, 2024, 479, 147654
10. Fan, F.; Xu, S.; Guo, M.; Cai, T.* Effect of organic acids on the solid-state polymorphic phase transformation of piracetam, International Journal of Pharmaceutics 2023,647, 123532
11. Xu, J.; Chen, A.; Cai, T.* “Polymorphism of purpurin and low-level detection of the noncentrosymmetric form by second harmonic generation microscopy” Journal of Pharmaceutical Sciences, 2023, 282-289
12. Chen, A.; Cai, P.; Luo, M.; Guo, M.; Cai, T.*; “Melt Crystallization of Celecoxib‑Carbamazepine Cocrystals with the Synchronized Release of Drugs” Pharmaceutical Research 2023,40, 567–577
13. Chen, J.1; Guo, M.1; Fan, R.; Peng, Y.; Cai, T.* Impact of Bile Salt on Solution-mediated Phase Transformation of Pharmaceutical Cocrystals: the Importance of Coformer Release Kinetics. Chemical Engineering Journal, 2022, 435, 134928
14. Guo, M.; Sun, X.; Zhang, S.; Cai, T.* Modulation of Solid‑State Chemical Stability of Gabapentin by Pyridinecarboxylic Acid Pharmaceutical Research 2022, 39, 2305-2314
15. Peng, Y.; Cong, Y.; Lei, Y.; Sun, F.; Xu, M.; Zhang, J.; Fang, L.; Hong, H.;* and Cai, T.* Transforming Passive into Active: Multimodal Pheophytin-Based Carbon Dots Customize Protein Corona to Target Metastatic Breast Cancer Adv. Healthcare Mater. 2022, 2102270
16. Su, Y.; Bhunia, S.; Xu, S.; Chen, A.; Reddy C.M.*; Cai, T.* “Structure−Thermomechanical Property Correlation in Polymorphic Molecular Crystals Probed by the Nanoindentation Technique” Chemistry of Materials. 2021 33, 4821−4829
17. Zhang, J.; Liu Z.; Wu, H.; Cai, T.* “Effect of polymeric excipients on nucleation and crystal growth kinetics of amorphous fluconazole” Biomaterials Science 2021, 9, 4308−4316
18. Guo,M.; Sun, X.; Chen, J.; Cai, T.* “Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications” Acta Pharmaceutica Sinica B 2021, 11,2537-2564
19. Zhang, J.; Shi, Q.; Guo, M.; Liu, Z.; Cai, T.* Melt Crystallization of Indomethacin Polymorphs in the Presence of Poly(ethylene oxide): Selective Enrichment of Polymer at the Crystal-Liquid Interface” Mol. Pharmaceutics 2020, 17, 2064−2071
20. Shi. Q.; Moinuddin, S. M.; Cai, T.*. Advances in coamorphous drug delivery systems Acta Pharmaceutica Sinica B 2019,9,19-35