陈维
发布人:系统管理员  发布时间:2017-12-25   浏览次数:2

陈维,博士,2017年1月以特聘研究员引进,博士生导师,就职于中国药科大学工学院。2010年6月苏州大学应用化学专业硕士学位,并获得江苏省优秀硕士研究生学位论文荣誉(导师:钟志远教授);2013年9月荷兰特文特大学(University of Twente)高分子化学与生物材料专业博士学位(导师:Jan Feijen教授和苏州大学钟志远教授)。2013年8月至2017年2月德国柏林自由大学(FreieUniversität Berlin)博士后研究(合作导师:Rainer Haag教授),担任组内“新型微纳结构”研究方向负责人,指导和带领组内博士和博士后研究人员20余名;2015年1月开始主持德国亚历山大•洪堡博士后基金项目。主要研究兴趣涉及“多功能性智能可降解高分子纳米载体”、“功能性生物表界面涂层材料”、“微流控或静电纺技术制备功能性细胞支架”等,已在高分子化学、药剂学、生物材料领域的国际著名学术期刊如:J. Control. Release、Biomaterials、Small、Macromolecules、J. Mater. Chem. B、Chem. Commun.、Biomacromolecules等发表论文20余篇,其中以第一作者或通讯作者发表论文18篇,论文被引用1000余次。目前已获得授权的欧洲专利、美国专利和中国专利4项。

(课题组招聘博士后,诚邀具有有机化学、高分子化学、药学、生物医学等研究背景的研究人员加入。Email:w.chen@cpu.edu.cn;w.chen.chem@gmail.com

代表性论文目录(注*为通讯联系人):
1.     W. Chen*, Y. Hou, Z.X. Tu,L.Y. Gao, and R. Haag,pH-Degradable PVA-Based Nanogels via Photo-Crosslinking of Thermo-PreinducedNanoaggregates for Controlled Drug Delivery, J. Control. Release 2016, DOI:http://dx.doi.org/10.1016/j.jconrel.2016.10.032.
2.     W. Chen, Y. Zou, Z.Y.Zhong, and R. Haag,Cyclo(RGD)-decorated Reduction-responsive Nanogels Mediate Targeted Chemotherapy of Integrin Over-expressing Human Glioblastoma In Vivo, Small2016, DOI: 10.1002/smll.201601997.
3.     W. Chen, F.H.Meng, R Cheng, C. Deng, J. Feijen, and Z.Y.Zhong,Biodegradable Glycopolymer-b-Poly(ε-caprolactone) Block Copolymer Micelles: Versatile Construction, Tailored Lactose Functionality, and Hepatoma-Targeted Drug Delivery, J. Mater. Chem. B. 2015, 3, 2308-2317.引用次数:12.
4.     W. Chen, K.Achazi, B.Schade, and R. Haag, Charge-Conversional and Reduction-Sensitive Poly(vinyl alcohol) Nanogels for Enhanced Cell Uptake and Efficient Intracellular Doxorubicin Release, J. Control. Release2015,205, 15-24.引用次数:12
5.     W. Chen, F.H.Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y.Zhong, Facile Construction of Dual-Bioresponsive Biodegradable Micelles with Superior Extracellular Stability and Activated Intracellular Drug Release, J. Control. Release 2015,210, 125-133.引用次数:32
1.     L.Y. Gao, B. Zheng, W. Chen*, and C.A. Schalley, Enzyme-Responsive-Based Polymer-Substituted Pillar[5]areneAmphiphiles: Synthesis, Self-Assembly in Water, and Application in Controlled Drug Release, Chem. Commun.2015,51, 14901-14904.引用次数:6
6.     W. Chen, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong, Advanced Drug and Gene Delivery Systems Based on Functional Biodegradable Polycarbonates andCopolymers, J. Control. Release 2014, 190, 398-414.引用次数:34.
7.     W. Chen, Y. Zou, F.H.Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y.Zhong, Glyco-Nanoparticles with Sheddable Saccharide Shells: A Unique and Potent Platform for Hepatoma-Targeting Drug Delivery, Biomacromolecules2014, 15, 900-907.引用次数:38
1.     W. Chen, Y. Zou, J.N. Jia, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong, Functional Poly(ε-caprolactone)s via Copolymerizing ε-Caprolactone with Pyridyldisulfide-Functionalized Cyclic Carbonate Monomer: Controlled Synthesis and Facile Access to Reduction-Sensitive Biodegradable Graft Copolymer Micelles, Macromolecules2013, 46, 699–707.引用次数:49
2.     W. Chen, M. Zheng, F.H.Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y.Zhong, In-Situ Forming Reductively Degradable Nanogels: Controlled Synthesis, Efficient Protein Encapsulation and Triggered Intracellular Release, Biomacromolecules201314, 1214-1222.引用次数:46
3.     W. Chen, P. Zhong, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong, Redox and pH-Responsive Degradable Micelles for Dually Activated Intracellular Anticancer Drug Release, J. Control. Release2013, 169, 171-179.引用次数:133
4.     R. Wang, W. Chen (co-first author), F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong, Unprecedented Access to Functional Biodegradable Polymers and Coatings, Macromolecules2011, 44, 6009–6016.引用次数:54
5.     W. Chen, F.H. Meng, R. Cheng, Z.Y. Zhong,pH-Sensitive Degradable Polymersomes for Triggered Release of Anticancer Drugs: a Comparative Study with Micelles, J. Control. Release2010, 142, 40-46.引用次数:220,苏州市自然科学优秀学术论文二等奖
6.     W. Chen, H.C. Yang, R. Wang, R. Cheng, F.H. Meng, W.X. Wei, and Z.Y. Zhong, Versatile Synthesis of Functional Biodegradable Polymers by Combining Ring-Opening Polymerization and Post-polymerization Modification via Michael-type Conjugate Addition Reactions, Macromolecules 2010, 43, 201-207.引用次数:96
7.     W. Chen, F.H. Meng, F. Li, S.J. Ji, and Z.Y. Zhong, pH-Responsive Biodegradable Micelles Based on Acid-Labile Polycarbonate Hydrophobe: Synthesis and Triggered Drug Release, Biomacromolecules2009, 7, 1727-1735.引用次数:146

授权专利:
1.     Wei Chen, Rong Wang, FenghuaMeng, and ZhiyuanZhong, A Method of Making A Polymer Preferably An (Alkyl)Acryloyl Polycarbonate, The Polymer and (Alkyl)Acryloyl Polycarbonate Obtained, and A Biodevice Comprising Same, European patent, 2016, No: EP2456764.
2.     Wei Chen, FenghuaMeng, Rong Wang, Ru Cheng, and ZhiyuanZhong, Method of Making An (Alkyl)Acryloyl Polycarbonate, US Patent, 2015, No: US8927196.
3.     钟志远,孟凤华,杜银锋,陈维,一种酸敏感可降解聚合物囊泡及其制备和应用,中国专利,2014,公开(公告)号:CN102911326.

4.     陈维,王荣,孟凤华,钟志远,含有丙烯酸酯类功能基团的环碳酸酯单体及其制备和应用,中国专利,2013,公开(公告)号:CN101633654.